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Nghiên cứu của các tác giả khác

Nghiên cứu của các tác giả khác (18)

The objective of this study was to examine the accuracy of a 12 MHz ultrasound catheter probe in the pre-operative staging of colorectal cancer by assessing the depth of tumour infiltration and involvement of pericolonic lymph nodes.

Despite the great breakthroughs we have witnessed in the last 50 years in the prevention, diagnosis, and treatment of hepatitis B, we are still far from eradicating or even curing the disease. Achieving further progress in controlling this disease will not be possible without discovering the exact pathogenesis behind it. One prime suspect in the pathogenesis of various diseases is oxidative stress. This review will exclusively explore hepatitis B in the context of oxidative stress to obtain a more comprehensive clinical perspective on its pathogenesis and eventual medical therapy.

Alcoholic liver disease (ALD) is a multifaceted disease that is characterized by hepatic steatosis or fat deposition and hepatitis or inflammation. Over the past decade, multiple lines of evidence have emerged on the mechanisms associated with ALD.

H. pylori is a pathogenic bacterium that parasitizes the gastric mucous layer and the epithelial lining of the stomach causing duodenal ulcers, gastric ulcers and cardiovascular disease amongst others. This study aimed at establishing the epidemiologic profle of H. pylori infection in gastritis patients presenting at the Melong District Hospital.

Upper gastrointestinal cancers represent a significant global health burden. Gastric and esophageal cancers were, respectively, the second and sixth most common causes of cancerrelated mortality worldwide in 2008, accounting for over one million deaths.

Background: This study aims to estimate the age-specific risks of clinical dengue attack (i.e., the risk of symptomatic dengue among the total number of dengue virus (DENV) infections) during primary and secondary infections.

Dengue virus is an important human pathogen that belongs to the Flaviviridae family. The viral genome is a single molecule of RNA of positive polarity that plays multiple roles during the viral life cycle. Besides encoding the viral proteins, the genome contains RNA structures that regulate different viral processes.

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Leopoldo G. Gebhard, Claudia V. Filomatori and Andrea V. Gamarnik

Abstract: Dengue virus (DENV) genome amplification is a process that involves the viral RNA, cellular and viral proteins, and a complex architecture of cellular membranes. The viral RNA is not a passive template during this process; it plays an active role providing RNA signals that act as promoters, enhancers and/or silencers of the replication process. RNA elements that modulate RNA replication were found at the 5' and 3' UTRs and within the viral coding sequence. The promoter for DENV RNA synthesis is a large stem loop structure located at the 5' end of the genome. This structure specifically interacts with the viral polymerase NS5 and promotes RNA synthesis at the 3' end of a circularized genome. The circular conformation of the viral genome is mediated by long range RNA-RNA interactions that span thousands of nucleotides. Recent studies have provided new information about the requirement of alternative, mutually exclusive, structures in the viral RNA, highlighting the idea that the viral genome is flexible and exists in different conformations. In this article, we describe elements in the promoter SLA and other RNA signals involved in NS5 polymerase binding and activity, and provide new ideas of how dynamic secondary and tertiary structures of the viral RNA participate in the viral life cycle. (Viruses 2011, 3, 1739-175)

Cao Minh Nga, Le Thi Kim Nhung, Nguyen Chi Cuong  * Y Hoc TP. Ho Chi Minh * Vol. 11 – Supplement of No 1 - 2007: 431 – 435

Background: Dengue Fever and Dengue Haemorrhagic Fever (DF/DHF) is a major global health problem, primarily of tropical and subtropical areas. Clinical diagnosis is based on criteria of WHO. Laboratory diagnosis is not applied.  Purpose: to detect and determine percentage of the anti-dengue IgM antibody on adult patients are diagnosed DF/DHF by clinical.

Method: descriptive and cross-sectional methods were used on 101 serum samples from patients at Thong nhat hospital from June 2006 to November 2006. MAC-ELISA (IgM antibody capture enzyme linked immunosorbent assay) was tested to detect the anti-dengue IgM antibody. 

Results: The majority of patients were detected in young (16-40 year olds). The positive anti-dengue IgM antibody is 62.38% in general. This percentage is higher in patiens with fever over 5 days and highest in group under 20 year olds patients – 73.91%

Conclusion: MAC-ELISA can be used in clinical surveillance for viral illness. It is useful for hospitalized adult patients and atypic clinical symptoms.

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Mục tiêu: Xác định sự phù hợp giữa lâm sàng và cận lâm sàng của bệnh sốt xuất huyết Dengue ở trẻ em tại Bệnh viện Nhi Đồng 2, trong thời gian từ 01/06/2007 đến 01/06/2008.

Phương pháp: Nghiên cứu hồi cứu trên 1170 trường hợp bệnh nhi làm xét nghiệm NS1 Ag và đối chiếu với chẩn đoán xuất viện. Từ đó chúng tôi xác định sự phù hợp giữa lâm sàng và cận lâm sàng của bệnh Sốt Xuất Huyết Dengue.

Kết quả: chỉ số Kappa = 0,7, cho thấy sự thống nhất đáng kể giữa kết quả lâm sàng và cận lâm sàng.

Kết luận: Chúng tôi nhận thấy xét nghiệm NS1 Ag có tính chính xác cao và chuyên biệt, xét nghiệm này giúp chúng ta chẩn đoán sớm hay loại trừ sớm bệnh Sốt Xuất Huyết.

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